Four people died, including two children, after they were rescued from a house fire in Hamilton overnight, authorities reported.

Hamilton fire crews responded to a fire in a row of townhouses at 14 Derby Street, near Rymal Road East and Upper Gage Avenue, shortly after 11 p.m. Thursday.

Hamilton Fire also received reports of people trapped on upper floors.

Crews entered and began a search for the occupants.

Two adults and two children were located on the second floor and crews began lifesaving measures.

All four people were transported to the hospital where they later died from their injuries.

Hamilton police tweeted that two other people were also transported to the hospital with serious injuries. Their conditions are unknown.